Cytoplasmic mislocalization of p 27 and cdk 2 mediates the anti - migratory and anti - 1 proliferative effects of Nodal in human trophoblast cells
نویسندگان
چکیده
Cytoplasmic mislocalization of p27 and cdk2 mediates the anti-migratory and anti1 proliferative effects of Nodal in human trophoblast cells 2 3 Lubna Nadeem, Jelena Brkic, Yangchun Frank Chen, Tung Bui, Sadia Munir and Chun Peng 4 Department of Biology, York University, Toronto, Canada 5 6 7 Running title: p27 and cdk2 mediate Nodal actions 8
منابع مشابه
Cytoplasmic mislocalization of p27 and CDK2 mediates the anti-migratory and anti-proliferative effects of Nodal in human trophoblast cells.
p27(Kip1), a cyclin-dependent kinase (CDK) inhibitor, is a multi-functional protein that regulates various cellular activities. Trophoblast proliferation, migration and invasion are some of the key processes of placental development. We have recently reported that Nodal, a member of the transforming growth factor-β (TGF-β) superfamily, inhibits human trophoblast cell proliferation, migration an...
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